解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Sea anemones are a remarkable source of active principles due to a decentralized venom system. New blood vessel growth or angiogenesis is a very promising target against cancer, but the few available antiangiogenic compounds have limited efficacy. In this study, a protein fraction, purified from tentacles of Anemonia ...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md16040134
更新日期:2018-04-19 00:00:00
abstract::Oxidative stress is the main cause of diabetic nephropathy (DN) progression. Nuclear factor-erythroid 2-related factor 2 (Nrf2)/antioxidant response element (ARE) signaling is a crucial cellular defense system to cope with oxidative stress. Astaxanthin (AST) is a fat-soluble xanthophyll carotenoid with remarkable anti...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md16040117
更新日期:2018-04-05 00:00:00
abstract::Collagen is involved in the formation of complex fibrillar networks, providing the structural integrity of tissues. Its low immunogenicity and mechanical properties make this molecule a biomaterial that is extremely suitable for tissue engineering and regenerative medicine (TERM) strategies in human health issues. Her...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md16040111
更新日期:2018-03-29 00:00:00
abstract::The 7-Acetylsinumaximol B (7-AB), a bioactive cembranoid, was originally discovered from aquaculture soft coral Sinularia sandensis. The current study investigated the anti-proliferative property of 7-AB towards the NCI-N87 human gastric cancer cell line. An MTT cell proliferative assay was applied to evaluate cell su...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md16040104
更新日期:2018-03-26 00:00:00
abstract::Natural O-alkyl-glycerolipids, also known as alkyl-ether-lipids (AEL), feature a long fatty alkyl chain linked to the glycerol unit by an ether bond. AEL are ubiquitously found in different tissues but, are abundant in shark liver oil, breast milk, red blood cells, blood plasma, and bone marrow. Only a few AEL are com...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md16040101
更新日期:2018-03-23 00:00:00
abstract::Three new polyoxygenated steroids, michosterols A-C (1-3), and four known compounds (4-7) were isolated from the ethyl acetate (EtOAc) extract of the soft coral Lobophytum michaelae, collected off the coast of Taitung. The structures of the new compounds were elucidated on the basis of spectroscopic analyses and compa...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md16030093
更新日期:2018-03-13 00:00:00
abstract::A member of the marine streptomycete clade MAR4, Streptomyces sp. CNQ-509, has genetic potential for the biosynthesis of hybrid isoprenoids and produces several meroterpenoids such as naphterpin, nitropyrrolin and marinophenazine. Our research on the strain CNQ-509 led to the isolation of two new naphterpin derivative...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md16030090
更新日期:2018-03-12 00:00:00
abstract::During blooms, cyanobacteria produce diverse modified peptides. Among these are the microginins, which inhibit zinc-containing metalloproteases. Ten microginins, microginins KR767 (1), KR801(2), KR835 (3), KR785 (4), KR604 (5), KR638 (6), KR781 (7), KR815 (8), FR3 (9), and FR4 (10), were isolated from the extract of a...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md16030078
更新日期:2018-03-02 00:00:00
abstract::Microalgae are promising sources for the sustainable production of compounds of interest for biotechnologies. Compared to higher plants, microalgae have a faster growth rate and can be grown in industrial photobioreactors. The microalgae biomass contains specific metabolites of high added value for biotechnology such ...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md16030076
更新日期:2018-02-28 00:00:00
abstract::The genus Streptomyces produces secondary metabolic compounds that are rich in biological activity. Many of these compounds are genetically encoded by large secondary metabolism biosynthetic gene clusters (smBGCs) such as polyketide synthases (PKS) and non-ribosomal peptide synthetases (NRPS) which are modular and can...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md16020067
更新日期:2018-02-20 00:00:00
abstract::Gut microbiota has been proved to be an indispensable link between nutrient excess and metabolic syndrome, and chitin oligosaccharide (NACOS) has displayed therapeutic effects on multiple diseases such as cancer and gastritis. In this study, we aim to confirm whether NACOS can ameliorate high-fat diet (HFD)-induced me...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md16020066
更新日期:2018-02-19 00:00:00
abstract::Despite the increasing availability of new classes of cancer treatment, such as immune- and targeted therapies, there remains a need for the development of new antiproliferative/cytotoxic drugs with improved pharmacological profiles that can also overcome drug resistant forms of cancer. In this study, we have identifi...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md16020063
更新日期:2018-02-15 00:00:00
abstract::A novel tetranorditerpenoid, sinubatin A (1) (having an unprecedented carbon skeleton), a new norditerpenoid, sinubatin B (2) (a 4,5-epoxycaryophyllene possessing an unusual methylfuran moiety side chain), and a known diterpenoid, gibberosin J (3) were isolated from soft coral Sinulariananolobata. The structures of th...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md16020040
更新日期:2018-01-24 00:00:00
abstract::Marine biotoxin-contaminated seafood has caused thousands of poisonings worldwide this century. Given these threats, there is an increasing need for improved technologies that can be easily integrated into coastal monitoring programs. This study evaluates approaches for monitoring toxins associated with recurrent toxi...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md16010028
更新日期:2018-01-13 00:00:00
abstract::Seagrasses are high plants sharing adaptive metabolic features with both terrestrial plants and marine algae, resulting in a phytocomplex possibly endowed with interesting biological properties. The aim of this study is to evaluate the in vitro activities on skin cells of an ethanolic extract obtained from the leaves ...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md16010021
更新日期:2018-01-10 00:00:00
abstract::Aaptos is a genus of marine sponge which belongs to Suberitidae and is distributed in tropical and subtropical oceans. Bioactivity-guided fractionation of Aaptos sp. methanolic extract resulted in the isolation of aaptamine, demethyloxyaaptamine, and isoaaptamine. The cytotoxic activity of the isolated compounds was e...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md16010018
更新日期:2018-01-09 00:00:00
abstract::Impaired wound healing is a major clinical problem in patients with diabetes and is the leading cause of lower limb amputation. This study is aimed to observe the effects of small molecule oligopeptides isolated from sea cucumber (SCCOPs) on the wound healing process in diabetic mice. Ninety db/db male mice were divid...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md16010016
更新日期:2018-01-08 00:00:00
abstract::Collagenases are the most important group of commercially-produced enzymes. However, even though biological resources are abundant in the sea, very few of these commercially popular enzymes are from marine sources, especially from marine bacteria. We optimized the production of marine collagenases by Pseudoalteromonas...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md15120377
更新日期:2017-12-04 00:00:00
abstract::Ice-binding protein (IBPs) protect cells from cryo-injury during cryopreservation by inhibiting ice recrystallization (IR), which is a main cause of cell death. In the present study, we employed two IBPs, one, designated LeIBP from Arctic yeast, and the other, designated FfIBP from Antarctic sea ice bacterium, in the ...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md15120372
更新日期:2017-12-01 00:00:00
abstract::Fish oil is used in the production of feed for cultured fish owing to its high polyunsaturated fatty acid content (PUFA). The over-exploitation of fisheries and events like "El Niño" are reducing the fish oil supply. Some marine microorganisms are considered potentially as alternative fatty acid sources. This study as...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md15120369
更新日期:2017-12-01 00:00:00
abstract::Oceans have shown to be a remarkable source of natural products. The biological properties of many of these compounds have helped to produce great advances in medicinal chemistry. Within them, marine natural products containing an oxepanyl ring are present in a great variety of algae, sponges, fungus and corals and sh...
journal_title:Marine drugs
pub_type: 杂志文章,评审
doi:10.3390/md15110361
更新日期:2017-11-15 00:00:00
abstract::Nowadays, various drugs on the market are becoming more and more resistant to numerous diseases, thus declining their efficacy for treatment purposes in human beings. Antibiotic resistance is one among the top listed threat around the world which eventually urged the discovery of new potent drugs followed by an increa...
journal_title:Marine drugs
pub_type: 杂志文章,评审
doi:10.3390/md15110354
更新日期:2017-11-10 00:00:00
abstract::Six kinds of chitinous materials have been used as sole carbon/nitrogen (C/N) sources for producing α-glucosidase inhibitors (aGI) by Paenibacillus sp. TKU042. The aGI productivity was found to be highest in the culture supernatants using demineralized crab shell powder (deCSP) and demineralized shrimp shell powder (d...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md15110350
更新日期:2017-11-07 00:00:00
abstract::Resistance to chemotherapy occurs in various diseases (i.e., cancer and infection), and for this reason, both are very difficult to treat. Therefore, novel antimicrobial and chemotherapic drugs are needed for effective antibiotic therapy. The aim of the present study was to assess the antimicrobial and anti-proliferat...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md15110342
更新日期:2017-11-01 00:00:00
abstract::The immunomodulatory effect of triterpene glycoside cucumarioside A₂-2 (CA₂-2), isolated from the Far Eastern sea cucumber Cucumaria japonica, was compared with lipopolysaccharide (LPS) on mouse spleen. It has been shown that the intraperitoneal (i.p.) glycoside administration leads to increased spleen macrophage acti...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md15110341
更新日期:2017-11-01 00:00:00
abstract::Sea cucumbers belonging to echinoderm are traditionally used as tonic food in China and other Asian countries. They produce abundant biologically active triterpene glycosides. More than 300 triterpene glycosides have been isolated and characterized from various species of sea cucumbers, which are classified as holosta...
journal_title:Marine drugs
pub_type: 杂志文章,评审
doi:10.3390/md15100317
更新日期:2017-10-17 00:00:00
abstract::Application of cytostatics in cancer patients' chemotherapy results in a number of side effects, including the inhibition of various parts of hematopoiesis. Two sulfated polysaccharides, fucoidan from the seaweed Chordaria flagelliformis (PS-Fuc) and fucosylated chondroitin sulfate from the sea cucumber Massinium magn...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md15100301
更新日期:2017-09-30 00:00:00
abstract::Padina sanctae-crucis Børgesen is distributed worldwide in tropical and subtropical seas; belongs to the Dictyotaceae family, and has proven to be an exceptional source of biologically active compounds. Four compounds were isolated and identified, namely: dolastane diterpene new for the genus Padina; phaeophytin and h...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md15100251
更新日期:2017-09-26 00:00:00
abstract::The authors wish to correct Figure 1 in this paper [1] to be as follows:[...]. ...
journal_title:Marine drugs
pub_type: 杂志文章,已发布勘误
doi:10.3390/md15090292
更新日期:2017-09-20 00:00:00
abstract::We aimed to investigate the pharmacokinetics and the underlying mechanisms of the intestinal absorption, distribution, metabolism, and excretion of Jaspine B in rats. The oral bioavailability of Jaspine B was 6.2%, but it decreased to 1.6% in bile-depleted rats and increased to 41.2% (normal) and 23.5% (bile-depleted)...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md15090279
更新日期:2017-09-01 00:00:00
abstract::Being able to quantify ichthyotoxic metabolites from microalgae allows for the determination of ecologically-relevant concentrations that can be simulated in laboratory experiments, as well as to investigate bioaccumulation and degradation. Here, the ichthyotoxin karmitoxin, produced by Karlodinium armiger, was quanti...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md15090278
更新日期:2017-08-31 00:00:00
abstract::Ciguatoxins (CTXs) are marine toxins that cause ciguatera fish poisoning, a debilitating disease dominated by sensory and neurological disturbances that include cold allodynia and various painful symptoms as well as long-lasting pruritus. Although CTXs are known as the most potent mammalian sodium channel activator to...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md15090269
更新日期:2017-08-30 00:00:00
abstract::The carbonic anhydrase (CA, EC 4.2.1.1) superfamily of metalloenzymes catalyzes the hydration of carbon dioxide to bicarbonate and protons. The catalytically active form of these enzymes incorporates a metal hydroxide derivative, the formation of which is the rate-determining step of catalytic reaction, being affected...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md15090270
更新日期:2017-08-28 00:00:00
abstract::Abstract: A new cyclopentenone, 5-hydroxycyclopeni cillone (1), was isolated together with three known compounds, ar-turmerone (2), citreoisocoumarin (3), and 6-O-methyl-citreoisocoumarin (4), from a culture of the sponge-derived fungus Trichoderma sp. HPQJ-34. The structures of 1-4 were characterized using comprehens...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md15080260
更新日期:2017-08-19 00:00:00
abstract::Nine new sulfated triterpene glycosides, magnumosides A₁ (1), A₂ (2), A₃ (3), A₄ (4), B₁ (5), B₂ (6), C₁ (7), C₂ (8) and C₄ (9) as well as a known colochiroside B₂ (10) have been isolated from the tropical Indo-West Pacific sea cucumber Neothynidium (=Massinium) magnum (Phyllophoridae, Dendrochirotida) collected in th...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md15080256
更新日期:2017-08-16 00:00:00
abstract::Sulphated polysaccharides with anti-thrombotic and anti-coagulant activities have been found in various marine biota. In this study, a previously characterised anti-thrombotic and anti-coagulant extract from blacklip abalone was fractionated by anion exchange chromatography (AEC), pooled (on a sulphated polysaccharide...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md15080240
更新日期:2017-08-04 00:00:00
abstract::Conotoxins in the venom of cone snails (Conus spp.) are a mixture of active peptides that work as blockers, agonists, antagonists, or inactivators of various ion channels. Recently we reported a high-throughput method to identify 215 conotoxin transcripts from the Chinese tubular cone snail, C. betulinus. Here, based ...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md15070228
更新日期:2017-07-18 00:00:00
abstract::Species in the genus Gambierdiscus produce ciguatoxins (CTXs) and/or maitotoxins (MTXs), which may cause ciguatera fish poisoning (CFP) in humans if contaminated fish are consumed. Species of Gambierdiscus have previously been isolated from macroalgae at Rangitahua (Raoul Island and North Meyer Islands, northern Kerma...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md15070219
更新日期:2017-07-11 00:00:00
abstract::Pseudomonas stutzeri 273 is a marine bacterium producing exopolysaccharide 273 (EPS273) with high anti-biofilm activity against P. aeruginosa PAO1. Here, the complete genome of P.stutzeri 273 was sequenced and the genome contained a circular 5.03 Mb chromosome. With extensive analysis of the genome, a genetic locus co...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md15070218
更新日期:2017-07-10 00:00:00
abstract::24-methyl-cholesta-5,24(28)-diene-3β,19-diol-7β-monoacetate (MeCDDA) is a natural steroid compound isolated from a wild-type soft coral (Nephthea erecta). The present study aimed to investigate the anti-small cell lung cancer (SCLC) effects of MeCDDA in vitro and in vivo, as well as to elucidate its underlying mechani...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md15070210
更新日期:2017-07-01 00:00:00